Table 1. Study population characteristics in relation to lifetime maternal history of diagnosed vitamin D deficiency.
Maternal history of vitamin D deficiency | ||||
---|---|---|---|---|
Characteristic | No | Yes | P | All |
Individuals, n (%) | 509 092 (99.9) | 547 (0.1) | 509 639 (100.0) | |
Cases of ASD with intellectual disability, n (%) | 2463 (0.5) | 13 (2.4) | <0.0001 | 2476 (0.5) |
Cases of ASD without intellectual disability, n (%) | 7396 (1.4) | 10 (1.8) | 0.46 | 7406 (1.4) |
Male (%) | 51.3 | 52.6 | 0.51 | 51.3 |
Maternal age, years: mean | 29.9 | 28.5 | <0.0001 | 29.9 |
Paternal age, years: mean | 32.8 | 34.0 | <0.0001 | 32.8 |
Maternal country of birth (%) | ||||
Sweden | 76.3 | 19.2 | <0.0001 | 76.2 |
Europe | 8.3 | 4.6 | 0.002 | 8.3 |
Outside Europe | 12.8 | 38.9 | <0.0001 | 12.9 |
Sub-Saharan Africa | 2.6 | 37.3 | <0.0001 | 2.6 |
Lowest quintile of disposable family income (%) | 14.8 | 35.6 | <0.0001 | 14.8 |
Elementary maternal education (%) | 15.6 | 43.1 | <0.0001 | 15.6 |
Elementary paternal education (%) | 16.8 | 32.7 | <0.0001 | 16.8 |
Born small for gestational age (%) | 2.5 | 3.7 | 0.09 | 2.5 |
Premature birth (<37 weeks, %) | 5.9 | 6.2 | 0.07 | 5.9 |
Maternal history of neuropsychiatric disorder (%)a | 2.4 | 9.3 | <0.0001 | 2.4 |
Paternal history of neuropsychiatric disorder (%)a | 2.0 | 2.0 | 0.98 | 2.0 |
Maternal history of affective disorder (%)b | 15.4 | 36.8 | <0.0001 | 15.4 |
Paternal history of affective disorder (%)b | 8.1 | 10.8 | 0.02 | 8.1 |
Maternal history of epilepsy (%) | 1.0 | 1.5 | 0.25 | 1.0 |
Paternal history of epilepsy (%) | 1.0 | 0.7 | 0.52 | 1.0 |
Parental histories of neuropsychiatric disorder include any in-patient or secondary care out-patient record of diagnosed non-affective psychosis, bipolar disorder, attention-deficit hyperactivity disorder, ASD, or intellectual disability.
Parental histories of affective disorder include any in-patient or secondary care out-patient record of diagnosed affective disorder except for bipolar disorder.
ASD, autism spectrum disorder.