a: The four gene risk score (SLC22A18 + PIGR + GJA12 + RIN2) had the best AUC of 0.988 (P<0.01).
b: Graphical representation of percentage of patients falling into each group. The probability of HDG/early EAC increases with an increase in the number of positive biomarkers (BE=Barrett’s esophagus, LGD=low grade dysplasia, HGD=high grade dysplasia, EAC=esophageal adenocarcinoma).