Table 1.
DNA methylation changes observed from the Illumina Infinium 27K array analysis comparing 24 EAC and 22 BE cases (total number of probes on the array=27,578, total number of genes=14,475)
| Trends (EAC vs. BE) | Number of probes | Percentage of probes | Number of genes | Percentage of genes | Number of probes within CpG islands | Number of probes outside of CpG Islands | |
|---|---|---|---|---|---|---|---|
| All genes | Hypermethylation | 1952 | 7.1 | 1764 | 12.18 | 1389 | 563 |
| Hypomethylation | 1740 | 6.3 | 1590 | 10.98 | 1114 | 626 | |
| Total | 3692 | 13.4 | 3354 | 23.16 | 2503 | 1189 | |
| Imprinted genes | Hypermethylation | 33 | 8.5 | 17 | 33.33 | 29 | 4 |
| Hypomethylation | 27 | 6.9 | 18 | 35.29 | 24 | 3 | |
| Total | 60 | 15.4 | 35 | 68.62 | 53 | 7 | |
| X-chromosome genes (males only) | Hypermethylation | 24 | 2.2 | 22 | 3.66 | 20 | 4 |
| Hypomethylation | 24 | 2.2 | 22 | 3.66 | 12 | 12 | |
| Total | 48 | 4.4 | 44 | 7.33 | 32 | 16 | |