Adjusted for age, sex, marital status, household income, education, region, alcohol consumption, physical activity, BMI, history of hypertension and history of diabetes. MDE, major depressive episodes. “Smoking(-) & MDE(-)” was used as the reference group. Squares represent the hazard ratios (HR) and vertical lines represent the corresponding 95% confidence intervals (95% CI). Numbers above the CIs are the HRs and numbers below the CIs represent participants with stroke events.