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. Author manuscript; available in PMC: 2017 Aug 4.
Published in final edited form as: Nature. 2016 Aug 4;536(7614):108–111. doi: 10.1038/nature18961

Extended Data Figure 6. Cryo-EM density map for the pore-helix of the GluA2 receptor.

Extended Data Figure 6

Clear density (blue mesh) is present for the pore-lining M2 helices, secondary structure elements that are weak or absent in all previous crystal structures. The N-terminus of each pore helix is involved in extensive interactions with TM4 from TARP subunits and we suggest that interactions of receptor TM helices that include M2, with TARP TM helices, stabilize the ion channel pore.