Table 2.
Antiviral activity of compounds 7a–7n.
| Sr. No. | n | R1 | R2 | Heterocycle (positiona) | Dengue |
Yellow fever |
||||
|---|---|---|---|---|---|---|---|---|---|---|
| EC50 (μM) | CC50 (μM) | SI | EC50 (μM) | CC50 (μM) | SI | |||||
| 7a | 0 | F | p-methyl | D1 (ortho) | 0.5 | >117 | >235 | ND | ND | NA |
| 7b | 0 | F | p-methyl | D2 (ortho) | 4.0 | >117 | >29 | 23.2 | >37 | >1.6 |
| 7c | 0 | CH3 | p-methyl | D1 (ortho) | 29 | >117 | >4 | ND | ND | NA |
| 7d | 0 | CH3 | p-methyl | D2 (ortho) | 14 | >117 | >8 | 23.2 | >37 | >1.6 |
| 7e | 0 | CH3 | p-methyl | D3 (ortho) | 2.0 | >114 | >57 | 6.8 | 23 | 3.4 |
| 7f | 0 | F | p-methyl | D3 (ortho) | 2.9 | >113 | >39 | 6.8 | >113 | >17 |
| 7g | 0 | CH3 | p-methyl | D4 (ortho) | 0.7 | 12.9 | 41 | 1.9 | >117 | >60 |
| 7h | 0 | F | p-methyl | D4 (ortho) | 3.0 | 47 | 16 | 6.5 | 67 | 10 |
| 7i | 1 | F | H | D4 (ortho) | 3.0 | 50 | 17 | 1.4 | 75 | 53 |
| 7j | 1 | CH3 | H | D4 (ortho) | 3.0 | 50 | 17 | 2.6 | 61 | 23 |
| 7k | 1 | F | H | D4 (para) | 16 | >116 | >7 | 7.4 | >117 | >16 |
| 7l | 1 | CH3 | H | D4 (para) | 13.8 | >117 | >8 | 3.3 | >117 | >35 |
| 7m | 0 | F | H | D1 (ortho) | >120 | >120 | 1 | 12.0 | >120 | >10 |
| 7n | 0 | CH3 | H | D1 (ortho) | 14.1 | >122 | >9 | 5.8 | >122 | >21 |
a
indicates the attachment point of the heterocycle on the phenyl ring.