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Antiviral activity of compounds 13a–13d having a reversed amide bond.
| Sr. No. | Heterocycle (positiona) | Dengue |
Yellow fever |
||||
|---|---|---|---|---|---|---|---|
| EC50 (μM) | CC50 (μM) | SI | EC50 (μM) | CC50 (μM) | SI | ||
| 13a | D4 | >116 | >116 | NA | >116 | >116 | NA |
| 13b | D3 | 3.2 | >113 | >35 | >113 | >113 (12.5 visual) | 1 |
| 13c | Pyridin-4-yl | 17 | >117 | >7 | >117 | >50 (30 visual) | 1 |
| 13d | Pyridin-3-yl | 23 | >117 | >5 | >117 | >50 (39 visual) | 1 |
Indicates the attachment point of the heterocycle on the phenyl ring.
