Table 3. The combination model of one-carbon metabolism-related gene polymorphisms between controls and RIF patients.
| 1st SNP | 2nd SNP | Controls | RIF patients | AOR (95% CI) | P | FDR-P |
|---|---|---|---|---|---|---|
| MTHFR 677C>T | MTHFR 1298A>C | n = 125 | n = 120 | |||
| CC | AA | 21 (16.8) | 13 (10.8) | 1.000 (reference) | ||
| CC | AC | 22 (17.6) | 18 (15.0) | 1.358 (0.530―3.480) | 0.523 | 0.523 |
| CC | CC | 3 (2.4) | 4 (3.3) | 1.994 (0.375―10.612) | 0.418 | 0.523 |
| CT | AA | 43 (34.4) | 40 (33.3) | 1.486 (0.657―3.363) | 0.342 | 0.523 |
| CT | AC | 21 (16.8) | 20 (16.7) | 1.755 (0.662―4.652) | 0.258 | 0.523 |
| TT | AA | 15 (12.0) | 25 (20.8) | 2.764 (1.065―7.174) | 0.037 | 0.185 |
| MTHFR 677C>T | TSER 2R/3R | |||||
| CC+CT | 3R3R | 70 (56.0) | 65 (54.2) | 1.000 (reference) | ||
| CC+CT | 2R3R+2R2R | 40 (32.0) | 30 (25.0) | 0.843 (0.468―1.520) | 0.570 | 0.570 |
| TT | 3R3R | 12 (9.6) | 16 (13.3) | 1.388 (0.607―3.172) | 0.437 | 0.570 |
| TT | 2R3R+2R2R | 3 (2.4) | 9 (7.5) | 3.195 (0.823―12.407) | 0.093 | 0.279 |
| MTHFR 677C>T | TS 1494 0bp/6bp | |||||
| CC+CT | 0bp0bp | 62 (49.6) | 53 (44.2) | 1.000 (reference) | ||
| CC+CT | 0bp6bp+6bp6bp | 48 (38.4) | 42 (35.0) | 1.094 (0.623―1.920) | 0.754 | 0.858 |
| TT | 0bp0bp | 8 (6.4) | 6 (5.0) | 0.902 (0.291―2.793) | 0.858 | 0.858 |
| TT | 0bp6bp+6bp6bp | 7 (5.6) | 19 (15.8) | 3.186 (1.241―8.178) | 0.016 | 0.048 |
| MTHFR 1298A>C | TSER 2R/3R | |||||
| AA | 3R3R | 53 (42.4) | 51 (42.5) | 1.000 (reference) | ||
| AA | 2R3R+2R2R | 26 (20.8) | 27 (22.5) | 1.087 (0.559―2.114) | 0.805 | 0.805 |
| AC+CC | 3R3R | 29 (23.2) | 30 (25.0) | 1.123 (0.589―2.142) | 0.725 | 0.805 |
| AC+CC | 2R3R+2R2R | 17 (13.6) | 12 (10.0) | 0.738 (0.319―1.708) | 0.478 | 0.805 |
| MTHFR 1298A>C | TS 1494 0bp/6bp | |||||
| AA | 0bp0bp | 47 (37.6) | 34 (28.3) | 1.000 (reference) | ||
| AA | 0bp6bp+6bp6bp | 32 (25.6) | 44 (36.7) | 1.945 (1.024―3.694) | 0.042 | 0.126 |
| AC+CC | 0bp0bp | 23 (18.4) | 25 (20.8) | 1.484 (0.718―3.066) | 0.287 | 0.431 |
| AC+CC | 0bp6bp+6bp6bp | 23 (18.4) | 17 (14.2) | 1.012 (0.466―2.198) | 0.975 | 0.975 |
| TSER 2R/3R | TS 1494 0bp/6bp | |||||
| 3R3R | 0bp0bp | 53 (42.4) | 45 (37.5) | 1.000 (reference) | ||
| 3R3R | 0bp6bp+6bp6bp | 29 (23.2) | 36 (30.0) | 1.530 (0.809―2.892) | 0.191 | 0.573 |
| 2R3R+2R2R | 0bp0bp | 17 (13.6) | 14 (11.7) | 0.955 (0.423―2.158) | 0.912 | 0.912 |
| 2R3R+2R2R | 0bp6bp+6bp6bp | 26 (20.8) | 25 (20.8) | 1.166 (0.589―2.309) | 0.660 | 0.912 |
Adjusted by age of female participants.
RIF, recurrent implantation failure; SNP, single nucleotide polymorphism; AOR, adjusted odds ratio