Table 2. Differentially Expressed Genes in NP and PE Placentae.
| Absolute PE only | Absolute NP only | Relative PE/NP | ||
|---|---|---|---|---|
| Negatively Significant Genes | # of Negatively Significant Genes | 5146 | 846 | 2197 |
| % of Negatively Significant Genes | 31% | 5% | 13% | |
| Positively Significant Genes | # of Positively Significant Genes | 4394 | 1076 | 2152 |
| % of Positively Significant Genes | 26% | 6% | 13% | |
| Non-Significant Genes | # of Non-Significant Genes | 7161 | 14779 | 12352 |
| % of Non-Significant Genes | 43% | 88% | 74% |
A total of 167 microarray samples (PE = 68; NP = 99) were meta-analysed as case-to-control matched samples with Fisher’s method or as case (PE) only and control (NP) only with RankProd analysis. About 31% more genes were identified as differentially expressed (DE) in PE only than in case matched baseline (NP) subtraction PE. RankProd analysis Confidence at (1—alpha): 95.0%; False Significant Proportion: 0.05 or less; p value threshold for fisher’s metaP = 0.05. PE = Pre-eclampsia Placentae; NP = Normal Placentae.