Table 1. Genome-wide significant meta-analysis results for five traits.
Pittsburgh Sample | Denver Sample | Meta-Analysis | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Trait | SNP | Locus | Minor allele | MAF | N | Beta (se)a | p | MAF | N | Beta (se)a | p | p |
Cranial base width (Fig 1A) | rs17106852 | 14q21.1 (38038468) | G | 0.106 | 2368 | -1.104 (0.205) | 7.91 x 10−8 | 0.097 | 671 | -0.858 (0.406) | 3.51 x 10−2 | 1.01 x 10−8 |
rs6129564 | 20q12 (38904203) | A | 0.116 | 2368 | -1.210 (0.193) | 4.07 x 10−10 | 0.100 | 671 | -0.449 (0.412) | 2.77 x 10−1 | 1.65 x 10−9 | |
Intercanthal width (Fig 1H) | rs619686 | 1p13.3 (110218761) | G | 0.056 | 2426 | -0.763 (0.163) | 3.12 x 10−6 | 0.052 | 671 | -0.536 (0.186) | 4.12 x 10−3 | 4.70 x 10−8 |
rs11093404 | Xq13.2 (72289467) | A | 0.243 | 2426 | 0.427 (0.075) | 1.31 x 10−8 | 0.248 | 671 | 0.073 (0.075) | 3.32 x 10−1 | 4.16 x 10−8 | |
Nasal width (Fig 1K) | rs2424399 | 20p11.22 (21632545) | C | 0.235 | 2429 | 0.377 (0.070) | 9.53 x 10−8 | 0.300 | 671 | 0.177 (0.098) | 7.04 x 10−2 | 2.62 x 10−8 |
Nasal ala length (Fig 1N) | rs8007643 | 14q11.2 (21365801) | T | 0.067 | 2426 | 1.064 (0.186) | 1.19 x 10−8 | 0.069 | 671 | 0.221 (0.216) | 3.07 x 10−1 | 3.36 x 10−8 |
Upper facial depth (Fig 1B) | rs12786942 | 11q22.1 (101394765) | T | 0.119 | 2368 | 1.429 (0.317) | 6.95 x 10−6 | 0.105 | 670 | 1.674 (0.523) | 1.43 x 10−3 | 4.59 x 10−8 |
a Beta values determined based on minor allele