Table 2. Odds ratio and 95% confidence interval (CI) for new-onset metabolic syndrome according to different quartiles of AST-to-ALT ratios.

	Q1	Q2	Q3	Q4	p-value
All subjects	N = 576	N = 562	N = 630	N = 508
AST-to-ALT ratio	~ 1.04	1.04–1.25	1.25–1.5	1.5 ~
Incidence	149 (25.87%)	105 (18.68%)	79 (12.54%)	62 (12.2%)	<0.0001
Crude OR	1	0.658 (0.496–0.873)	0.411 (0.304–0.555)	0.398 (0.288–0.551)	<0.0001
Model 1	1	0.633 (0.476–0.842)	0.385 (0.284–0.522)	0.364 (0.262–0.505)	<0.0001
Model 2	1	0.755 (0.56–1.018)	0.505 (0.367–0.694)	0.571 (0.403–0.81)	0.0001
Model 3	1	0.778 (0.575–1.051)	0.522 (0.378–0.719)	0.598 (0.42–0.853)	0.0004
Excluding heavy drinkers	N = 527	N = 528	N = 578	N = 466
AST-to-ALT ratio	~ 1.04	1.04–1.26	1.26–1.5	1.5 ~
Incidence	137 (26%)	99 (18.75%)	69 (11.94%)	57 (12.23%)	<0.0001
Crude OR	1	0.657 (0.49–0.88)	0.386 (0.281–0.53)	0.397 (0.283–0.557)	<0.0001
Model 1	1	0.632 (0.47–0.848)	0.365 (0.265–0.503)	0.367 (0.261–0.517)	<0.0001
Model 2	1	0.759 (0.556–1.035)	0.494 (0.352–0.692)	0.595 (0.413–0.857)	0.0003
Model 3	1	0.786 (0.574–1.075)	0.513 (0.365–0.721)	0.627 (0.434–0.905)	0.0011

Data are OR (95% CI) or n (%). Model 1: adjusted for age. Model 2: Model 1, plus additional adjustment for baseline BMI, LDL cholesterol, smoking, regular exercise, and alcohol drinking. Model 3: Model 2, plus additional adjustment for baseline hs-CRP and HOMA-IR