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. 2016 Aug 25;11(8):e0161996. doi: 10.1371/journal.pone.0161996

Table 2. The top 20 substances that led to ICU admission for overdose.

Total (n = 676) Incidence (%)a
Substance n % Prolonged ICU stay Aspiration pneumonitis
Total 676 100.0 10.2 10.7
1. Flunitrazepam 178 26.3 10.1 15.7
2. Etizolam 121 17.9 8.3 10.7
3. Brotizolam 113 16.7 9.7 12.4
4. Zolpidem 105 15.5 8.6 11.4
5. Chlorpromazine-promethazine-phenobarbital 104 15.4 20.2 28.8
6. Triazolam 103 15.2 10.7 13.6
7. Bromazepam 91 13.5 12.1 16.5
8. Alprazolam 89 13.2 7.9 10.1
9. Valproate 82 12.1 7.3 8.5
10. Nitrazepam 71 10.5 9.9 16.9
11. Levomepromazine 63 9.3 4.8 15.9
12. Acetaminophen 61 9.0 11.5 0.0
13. Paroxetine 59 8.7 13.6 15.3
14. Fluvoxamine 58 8.6 12.1 17.2
15. Lorazepam 48 7.1 8.3 16.7
16. Risperidone 48 7.1 4.2 4.2
17. Diazepam 43 6.4 7.0 11.6
18. Estazolam 43 6.4 14.0 18.6
19. Chlorpromazine 41 6.1 14.6 17.1
20. Clonazepam 41 6.1 7.3 7.3

a The denominator was the number of patients who ingested a substance and the numerator was the number of incident cases among the patients.

ICU = intensive care unit