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. 2016 Aug 25;10(8):e0004907. doi: 10.1371/journal.pntd.0004907

Fig 3. Mp1p is a virulence factor of T. marneffei.

Fig 3

(A) Survival curves of Balb/c mice challenged with T. marneffei PM1, MP1 knockout mutant, MP1 complemented mutant and knockdown mutants (***P<0.0001). (B) Mean fungal burden in spleen, kidney, liver and lung of mice challenged with T. marneffei PM1, MP1 knockout mutant, MP1 complemented mutant and MP1 knockdown mutant at day 12 post-challenge (***P<0.001, **P<0.01, *P<0.05). Error bars represent standard deviations. (C) Histopathological examination of PAS stained internal organs of mice at day 12 post-challenge. T. marneffei yeast cells are shown in black arrows and tissue necrosis in blue arrows.