Table 1. Clinical characteristics of 535 female patients with IgAN stratified in quartiles of uric acid levels.
| Q1 | Q2 | Q3 | Q4 | P | |
|---|---|---|---|---|---|
| Uric acid (mg/dL) | 3.6 (0.2–3.9) | 4.3 (4.0–4.6) | 5.0 (4.7–5.4) | 6.2 (5.5–10.3) | |
| Number | 140 | 146 | 118 | 131 | |
| Baseline characteristics at renal biopsy | |||||
| Age (years) | 27 (22, 37) | 28 (23, 44) | 29 (22, 45) | 44 (30, 53) | <0.001 |
| Body mass index (kg/m2) | 20.6±2.7 | 21.0±3.0 | 21.9±3.9 | 24.0±3.9 | <0.001 |
| Hypertension (%)§ | 10.0 | 18.5 | 21.2 | 49.6 | <0.001 |
| Serum creatinine (mg/dL) | 0.60 (0.51, 0.69) | 0.60 (0.59, 0.70) | 0.68 (0.60, 0.80) | 0.85 (0.70, 1.07) | <0.001 |
| Urinary protein (g/day) | 0.24 (0.13, 0.53) | 0.30 (0.16, 0.62) | 0.44 (0.18, 0.86) | 0.64 (0.32, 1.70) | <0.001 |
| Current smoker (%) | 12.1 | 14.4 | 12.7 | 16.0 | 0.448 |
| Cigarettes (per day)# | 6 (5, 10) | 15 (10, 20) | 15 (10, 20) | 20 (10, 20) | 0.297 |
| Diabetes (%) | 0.8 | 0.7 | 0.8 | 0.8 | 0.927 |
| Therapeutic interventions within 1 year of kidney biopsy | |||||
| RAAS blockade (%) | 25.0 | 21.9 | 40.7 | 60.3 | <0.001 |
| Use of corticosteroids (%) | 18.6 | 28.8 | 41.5 | 26.0 | 0.047 |
Median (min—max), median (25%, 75%), mean±SD.
RAAS, renin-angiotensin aldosterone system
§Systolic blood pressure ≥140 mmHg, diastolic blood pressure ≥90 mmHg, and/or use of antihypertensive drugs at the time of kidney biopsy
#Number of cigarettes smoked in current smokers at the time of kidney biopsy was displayed. P value was calculated after including past and non-smokers with 0 cigarette per day.