The first step of Fig 2 appears erroneously in the publication as a repetition of Fig 1. The correct Fig 2 should show the oxidation of cannabidiol diacetate to 9-hydroxy-cannabidiol diacetate. Please see the correct Fig 2 here.
Fig 2. Synthesis of HUF-102(2).
Reagents and conditions: (a) SeO2, t-BuOOH, CH2Cl2, r.t; (b) DAST, CH2Cl2, 0°C.
Reference
- 1.Breuer A, Haj CG, Fogaça MV, Gomes FV, Silva NR, Pedrazzi JF, et al. (2016) Fluorinated Cannabidiol Derivatives: Enhancement of Activity in Mice Models Predictive of Anxiolytic, Antidepressant and Antipsychotic Effects. PLoS ONE 11(7): e0158779 doi: 10.1371/journal.pone.0158779 [DOI] [PMC free article] [PubMed] [Google Scholar]