Table 3.

Summary of outcomes, hypotheses, measures, and methods of analysis.

Analyses	Outcome	Hypothesis	Outcome measure	Method of analysis
Primary outcome
	8-week worst postop pain intensity upon movement score in the past 24 hours	Intervention > control	Measured by Brief Pain Inventory-Short Form (BPI-SFa)	Linear mixed model or nonlinear mixed models (if assumptions of normality are violated)
Secondary outcome
	Functional status	Intervention > control	Short-Form 12 version 2	Linear mixed model or nonlinear mixed models (if assumptions of normality are violated)
	Depressive symptom scores	Intervention > control	Five-question version of the Geriatric Depression Scale	Linear mixed model or nonlinear mixed models (if assumptions of normality are violated)
	Postop complications related to hemodynamic compromise	Intervention > control	Myocardial infarction and stroke	Nonlinear mixed models
	Other relevant postop complications	Intervention > control	Surgical site infection, presence of CPSPb	Nonlinear mixed models
	Heath service utilization-related cost	Intervention > control	Linked with health administrative Institute for Clinical Evaluative Sciences data repository	Linear mixed model or nonlinear mixed models (if assumptions of normality are violated)
	Patient-level cost of recovery	Intervention > control	Ambulatory and Home Care Record	Linear mixed model or nonlinear mixed models (if assumptions of normality are violated)
Subgroup outcomes
	All outcomes	Effect will differ by gender (male versus female)	Worst postop pain intensity upon movement score in the past 24 hours measured by BPI-SF numeric rating scale	Interaction test
	All outcomes	Effect will differ by GREPc scores (low versus high)	Worst postop pain intensity upon movement score in the past 24 hours measured by BPI-SF numeric rating scale	Interaction test

^aBPI-SF: Brief Pain Inventory-Short Form.

^bCPSP: chronic postsurgical pain.

^cGREP: Gender Role Expectations of Pain.