Table 5. P2X7R rs3751142 and CARD8 rs2043211 genotype combination between gout and controls.
| P2X7R/CARD8* | No. (frequency, %) | P value | OR (95% CI) | |
|---|---|---|---|---|
| Gout | Controls | |||
| CC/AA | 54 (22.3) | 57 (20.4) | 1 | |
| CC/AT | 93 (38.4) | 88 (31.4) | 0.507 | 1.180 (0.724, 1.923) |
| CC/TT | 33 (13.6) | 53 (18.9) | 0.292 | 0.728 (0.404, 1.314) |
| CA/AA | 17 (7.0) | 27 (9.6) | 0.540 | 0.796 (0.383, 1.652) |
| CA/AT | 27 (11.2) | 40 (14.3) | 0.470 | 0.791 (0.419, 1.494) |
| CA/TT | 16 (6.6) | 7 (2.5) | 0.056 | 2.618 (0.975, 7.031) |
| AA/AA | 0 (0.0) | 4 (1.4) | 0.999 | - |
| AA/AT | 1 (0.4) | 3 (1.1) | 0.505 | 0.455 (0.045, 4.615) |
| AA/TT | 1 (0.4) | 1 (0.4) | 0.999 | 1.002 (0.048, 20.775) |
The statistical analysis was performed using logistic regression analysis after adjustment with age.
OR, odds ratio; CI, confidence interval.
*rs3751142(C>A) in P2X7R gene and rs2043211(A>T) in CARD8.