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. 2016 Aug 11;16(8):2087–2101. doi: 10.1016/j.celrep.2016.07.059

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© 2016 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Early Stromal Recruitment in Mouse and Human CLC

(A and B) In (A), H&E and Masson’s trichrome staining (revealing collagen) and IHC of PDGFRβ (fibroblasts), CD3 (T cells), and F4/80 (macrophages) in tumor-free mammary glands and mCLCs from wild-type, Wcre;Cdh1^F/F, Wcre;Pten^F/F, and Wcre;Cdh1^F/F;Pten^F/F mice of indicated age were used to examine stromal compositions in each indicated genotype, which were subsequently compared to (B) the microenvironment of healthy human mammary glands and the tumor microenvironment of human CLCs.