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. 2016 Aug 26;9:77. doi: 10.3389/fnmol.2016.00077

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Copyright © 2016 Hong, Tian, Qi, Li, Du, Chen, Liu and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of GSK1016790A on I_GABA in hippocampal CA1 pyramidal neurons. (A) The representative recordings show that I_GABA (activated by 10 μM GABA) was inhibited from −3.1 to −2.0 nA by 0.3 μM GSK1016790A, and the current recovered to −2.8 nA after washout. (B) The plot shows inhibition of I_GABA by GSK1016790A at concentrations of 0.01, 0.03, 0.1, 0.3, 1, 3, and 5 μM. The dose-response curve fits the Hill equation, with IC₅₀value of 0.1 ± 0.05 μM and n of 1.09 ± 0.04. (C) Dose-response curves for I_GABA before and during GSK1016790A treatment. Each point represents the normalized current from 8 to 10 neurons. (D) I–V curves for I_GABA before and during GSK1016790A treatment. Each point represents the normalized current from 8 to 10 neurons.