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. 2016 Aug 26;9:77. doi: 10.3389/fnmol.2016.00077

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Copyright © 2016 Hong, Tian, Qi, Li, Du, Chen, Liu and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of 5,6-EET on I_GABA in hippocampal CA1 pyramidal neurons. (A,B) I_GABA (activated by 10 μM GABA) was inhibited by 300 nM 5,6-EET. The representative recordings show that I_GABA was −3.0, −2.2, and −2.7 nA before, during and after 5,6-EET treatment, respectively (A). On the average, I_GABA was reduced from −24.9±4.2 to −16.3±3.3 pA/pF. ^**P < 0.01 vs. control (B). (C) Dose-response curves for I_GABA before and during 5,6-EET treatment. Each point represents the normalized current from 8 to 10 neurons. (D) I–V curves for I_GABA in the absence and presence of 5,6-EET. Each point represents the normalized current from 8 to 10 neurons.