Table 3.
Sensitivity index calculated for steady state AUC0‐24h of UDCA (U) and its conjugates (G and T) in various tissue compartments for each parameter in the model for healthy subjects.
| Intestine | Portal | Blood | Liver | Biliary | Feces | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameters | U | G | T | U | G | T | U | G | T | U | G | T | U | G | T | U | G | T |
| KSI | 0.0 | −0.1 | −0.1 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.3 | −0.8 | −0.6 | 0.1 | 0.1 | 0.2 |
| KIP,0 | −89.1 | 91.1 | 91.1 | 91.1 | 91.1 | 91.1 | 91.1 | 91.1 | 91.1 | 91.1 | 91.1 | 91.1 | 92.0 | 92.3 | 91.8 | −89.5 | 90.4 | 90.4 |
| KPL,0 | 0.0 | −0.5 | −0.2 | −99.0 | 0.0 | 0.0 | −99.0 | 0.0 | 0.0 | 0.1 | 0.0 | 0.0 | 2.4 | −10.2 | −6.3 | 3.7 | 6.6 | 6.7 |
| KLB,0 | 2.0 | −2.7 | −2.7 | 2.3 | −2.7 | −2.7 | 2.3 | −2.7 | −2.7 | −2.8 | −2.7 | −2.7 | 99.0 | −2.7 | −2.7 | 2.4 | −2.7 | −2.7 |
| KBI,0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | −97.2 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| KIF,0 | −91.1 | −91.2 | −91.1 | −91.1 | −91.1 | −91.1 | −91.1 | −91.1 | −91.1 | −91.1 | −91.1 | −91.1 | −91.0 | −92.5 | −92.0 | 89.6 | −90.3 | −90.3 |
| KPB,0 | 0.0 | 0.2 | 0.1 | 0.0 | 0.0 | 0.0 | 99.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | −3.6 | 2.6 | 1.7 | −0.3 | −0.6 | −0.6 |
| KBP,0 | 0.0 | −0.1 | 0.0 | 0.0 | 0.0 | 0.0 | −99.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 1.3 | −2.6 | −1.6 | 0.3 | 0.6 | 0.6 |
| KCONJ,1 | 25.8 | 69.4 | −96.7 | 25.7 | 69.3 | −96.7 | 25.7 | 69.3 | −96.7 | −96.7 | 69.3 | −96.7 | −96.7 | 70.6 | −96.7 | 24.6 | 68.9 | −96.8 |
| KDECONJ,1 | 60.6 | −92.2 | 61.8 | 61.7 | −66.7 | 61.7 | 61.7 | −66.6 | 61.7 | 61.7 | −13.5 | 61.7 | 60.9 | −15.4 | 65.1 | 60.5 | −90.4 | 60.3 |
| KIP,1 | −4.2 | −17.4 | −21.4 | −2.5 | 95.3 | 98.2 | −2.5 | 95.4 | 98.3 | −2.5 | 85.5 | 92.9 | −2.1 | 87.5 | 93.8 | −15.1 | −25.8 | −37.6 |
| KPL,1 | 0.0 | 0.2 | 0.0 | 0.0 | −99.0 | 0.0 | 0.0 | −99.0 | 0.0 | 0.0 | 0.0 | 0.0 | 1.1 | −1.7 | 0.6 | 2.7 | 5.0 | 2.8 |
| KLP,1 | 0.0 | 0.1 | 0.0 | 0.0 | 87.8 | 0.0 | 0.0 | 87.8 | 0.0 | 0.0 | 0.0 | 0.0 | −0.2 | 4.1 | −0.4 | −1.2 | −2.3 | −1.3 |
| KLB,1 | 2.1 | 2.9 | 5.2 | 2.1 | −87.4 | −58.4 | 2.1 | −87.3 | −58.1 | 2.1 | −99.0 | −98.9 | 0.9 | −13.6 | −7.8 | 14.9 | 26.0 | 31.2 |
| KBI,1 | 0.3 | −1.0 | 0.7 | 0.7 | 0.9 | 1.2 | 0.8 | 1.1 | 1.9 | 0.8 | 1.0 | 1.5 | 3.8 | −97.4 | −97.4 | 10.8 | 18.7 | 23.7 |
| KIF,1 | −68.4 | −92.0 | −97.5 | −68.5 | −86.2 | −96.6 | −68.5 | −86.2 | −96.5 | −68.5 | −78.8 | −90.6 | −69.1 | −84.3 | −93.3 | −64.9 | 89.8 | 61.7 |
| KPB,1 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 99.0 | 99.0 | 0.0 | 0.0 | 0.0 | −0.7 | 0.9 | 0.2 | −1.0 | −1.8 | −1.3 |
| KBP,1 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | −99.0 | −99.0 | 0.0 | 0.0 | 0.0 | 0.4 | 0.5 | 0.2 | 1.0 | 1.8 | 1.3 |
| EMeal | −2.2 | −13.5 | −8.6 | 0.0 | −1.0 | −3.9 | 0.0 | 0.0 | −0.1 | 0.0 | 0.0 | 0.0 | −11.5 | −41.1 | −39.5 | 1.2 | 2.0 | 2.6 |
| ESnack | −0.3 | −2.0 | −1.3 | 0.0 | −0.1 | −0.5 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | −10.9 | −13.6 | −13.8 | 0.3 | 0.4 | 0.6 |
| KCONJ,2 | −26.7 | −69.0 | 96.8 | −26.9 | −69.0 | 96.8 | −26.9 | −69.0 | 96.8 | −69.0 | −69.0 | 96.8 | −68.9 | −70.3 | 96.7 | −25.8 | −68.5 | 96.8 |
| KDECONJ,2 | 16.7 | 16.9 | −86.9 | 16.8 | 16.8 | −83.1 | 16.8 | 16.8 | −82.9 | 16.8 | 16.8 | −58.5 | 16.9 | 18.7 | −62.1 | 15.9 | 15.8 | −85.6 |
| KPL,2 | 0.0 | 0.0 | 0.1 | 0.0 | 0.0 | −99.0 | 0.0 | 0.0 | −99.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | −1.7 | 0.1 | 0.1 | 0.9 |
| KLP,2 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 60.5 | 0.0 | 0.0 | 60.2 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.3 | 0.0 | 0.0 | −0.1 |
AUC, area under the curve; UDCA, ursodeoxycholic acid.
The color represents the relative magnitude of the Sensitivity index (SI) values with positive extreme value in dark red and negative extreme value in dark blue. Values in between are colored with lighter colors transitioning from the two extreme colors.