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. 2011 Apr 15;4(1):69–75. doi: 10.5005/jp-journals-10005-1085

Table 1: Summary of growth factors released from platelets

Growth factor      Molecular properties      Source cells      Target      Action     
PDGF      Cationic polypeptide (Mr = 30 kda)      Platelets, macrophages, monocytes, endothelial cells, smooth muscle cells.      Fibroblasts, smooth muscle cells, glial cells, macro-phages/neutrophils.      Stimulates chemotaxis/mitogen-esis in fibroblast/glial/smooth muscle cells; regulates collage-nase secretion/collagen synthesis; stimulates macrophage/neutrophil chemotaxis.     
TGF-b      2-chain polypeptide (Mr = 25 kda); 3 different gene products in humans: TGF-P1, TGF-P2, TGF-P3      Platelets, T-lymphocytes, macrophages/monocytes, neutrophils.      Fibroblasts, marrow stem cells, endothelial cells, epithelial cells, preosteoblasts.      Stimulates/inhibits endothelial, fibroblastic, and osteoblastic mitogenesis; regulates collagen synthesis/collagenase secretion; regulates mitogenic effects of other growth factors; stimulates endothelial chemotaxis and angio-genesis.     
PDEGF      53-amino acid poly-peptide (Mr = 6 kda)      Platelets, macrophages, monocytes.      Fibroblasts, endothelial cells, epithelial cells.      Stimulates endothelial chemo-taxis/angiogenesis; regulates collagenase secretion; stimulates epithelial/mesenchymal mitogen-esis.     
PDAF      Acidic polypeptide
(Mr = 45 kda)		      Platelets, endothelial cells.      Endothelial cells      Increases angiogenesis and vessel permeability; stimulates mito-genesis for endothelial cells by direct or indirect actions; several cytokines and growth factors up-regulate PDAF, including IGF-1, TGF-alpha and beta, PDGF,
bFGF, PDEGF, and IL-1 beta.		     
IGF-1      Single-chain polypeptide (Mr = 47 kda) 47% homology with insulin.      Osteoblasts, macro-phages, monocytes, chondrocytes.      Fibroblasts, osteoblasts, chondrocytes.      Stimulates cartilage growth, bone matrix formation, and replication of preosteoblasts and osteoblasts; acts as an autocrine and paracrine factor; in combination with PDGF can enhance the rate and quality of wound healing.     
PF-4      Homotetramer (Mr = 29 kda)      Platelets      Fibroblasts, neutrophils      Chemoattractant for neutrophils and fibroblasts; potent antiheparin agent.     

PDGF - platelet-derived growth factor; TFG-b - transforming growth factor beta; PDEGF - platelet-derived epidermal growth factor; PDAF - platelet-derived angiogenesis factor; IGF-1 - insulin-like growth factor 1; PF-4 - platelet factor 4; bFGF - basic fibroblast growth factor.