Figure 5.

Cl-amidine administration attenuates acute Sev-induced inflammatory responses. WT mice were administered Cl-amidine i.p. daily 2 days prior to infection and treatment was continued (twice a day) until sacrifice as detailed in Section “Materials and Methods.” Controls received the same i.p. regimen of DMSO/PBS (5% v/v). On day 3 BALF was collected; cells were enumerated and cell-free BALF assayed for cytokines by CBA. Values represent mean ± SEM, n = 5 mice/treatment group. **P < 0.01; ***P = 0.001; note that IL-6 level in Cl-amidine treatment group approached statistical significance (P = 0.06).