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. 2016 Aug 2;8(8):73. doi: 10.3390/cancers8080073

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© 2016 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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The relationship between C. elegans Wnt genes, IGF signaling, dietary restriction and the ELT circuit in aging. Two Wnt genes lin-44 and egl-20 extend lifespan while two others mom-2 and cwn-2 shorten it. Cwn-1 did not have a significant effect on lifespan. Wnts increase expression of elt-5, which along with elt-6 has increased expression with age. Both elt-5 and elt-6 repress expression of elt-3 whose expression decreases with age. Elt-3 is required for lifespan extension through the insulin pathway (daf-2) and dietary restriction (eat-2).