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Association of the Wnt pathway with stress responses and aging. Under stress conditions ROS is produced in the mitochondria, blocking the interaction of Nrx with Dsh and releasing Nrx inhibition of Dsh. β-catenin then preferentially interacts with FoxO to activate transcription. When no oxidative stress is present Nrx binds Dsh, and -catenin returns to its normal TCF preference.
