Table 3. Relationships of sphingolipid metabolites and the related enzymes with each clinical parameter.

Parameter	Sph		S1P		dhS1P
	Spearman’s rho	P value	Spearman’s rho	P value	Spearman’s rho	P value
*Sex		0.15		0.76		0.85
Age (years)	0.0650	0.58	−0.0285	0.81	−0.0556	0.64
Platelet count (×104/μL)	0.0406	0.73	−0.0481	0.68	0.0327	0.78
Albumin (g/dL)	0.1206	0.31	0.0934	0.43	0.0173	0.88
AST (U/L)	0.0780	0.51	0.0353	0.77	0.2387	0.04
ALT (U/L)	0.1678	0.15	0.0434	0.71	0.2504	0.03
GGT (U/L)	0.0010	0.93	−0.1471	0.21	0.1497	0.20
ALP (U/L)	−0.0741	0.53	−0.0157	0.89	0.1717	0.14
Total bilirubin (mg/dL)	0.2019	0.08	0.1244	0.29	0.2182	0.06
PT%	0.0803	0.50	−0.2055	0.08	−0.1854	0.11
SK1		SK2		SPL		SPP1
Spearman’s rho	P value	Spearman’s rho	P value	Spearman’s rho	P value	Spearman’s rho	P value
	0.17		0.85		0.21		0.25
−0.1114	0.33	0.1703	0.13	−0.0132	0.91	−0.2161	0.054
−0.1709	0.13	−0.0320	0.78	−0.1241	0.27	0.0077	0.95
0.1565	0.17	0.0864	0.45	0.0836	0.46	0.2433	0.03
0.3107	0.005	0.1048	0.35	0.1477	0.19	0.0796	0.48
0.4031	<0.001	0.1524	0.18	0.2491	0.03	0.2268	0.04
−0.0241	0.83	−0.2675	0.02	−0.2143	0.06	−0.0844	0.46
0.0697	0.54	−0.0237	0.98	−0.0211	0.85	−0.0114	0.92
0.2118	0.048	0.0170	0.88	−0.009	0.94	−0.0058	0.96
−0.1975	0.08	0.0062	0.96	−0.1176	0.30	−0.0349	0.76
SPNS2		S1P1		S1P2		S1P3
Spearman’s rho	P value	Spearman’s rho	P value	Spearman’s rho	P value	Spearman’s rho	P value
	0.42		0.76		0.15		0.24
0.0756	0.50	0.0254	0.82	0.0287	0.80	−0.0619	0.59
−0.1368	0.23	−0.0470	0.68	−0.1361	0.23	−0.1034	0.36
0.0699	0.54	0.1704	0.13	0.1149	0.31	0.2635	0.02
0.1529	0.18	0.1751	0.12	0.1848	0.10	0.2007	0.07
0.3024	0.006	0.2875	0.01	0.2699	0.01	0.2845	0.01
−0.1840	0.10	−0.1392	0.22	−0.1818	0.11	−0.0137	0.90
−0.0585	0.61	−0.0352	0.76	−0.0910	0.42	0.0237	0.83
−0.1347	0.91	0.0633	0.58	0.0454	0.69	−0.0058	0.96
−0.0503	0.66	0.0016	0.99	−0.0666	0.56	−0.6647	0.56

^*Relation of each variable with sex is analyzed using Mann-Whitney U test.

Sph, sphingosine; S1P, sphingosine-1-phosphate; SK, sphingosine kinase; SPL, sphingosine-1-phosphate lyase; SPP1, sphingosine-1-phosphate phosphatase 1; SPNS2, S1P transporter spinster homolog 2; S1P1, sphingosine 1-phosphate receptor 1; S1P2, sphingosine 1-phosphate receptor 2; S1P3, sphingosine 1-phosphate receptor 3; AST, aspartate aminotransferase; ALT, alanine aminotransferase; GGT, γ-glutamyl transpeptidase; ALP, alkaline phosphatase; PT, prothrombin time.