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Major epigenetic modifications at the FMR1 locus in transcriptionally active (wild type (WT) and unmethylated full mutation (UFM)) and inactive fragile X syndrome (FXS) alleles.
| WT | FXS | UFM | |
|---|---|---|---|
| DNA methylation | − (absent) | + (present) | − (absent) |
| H3 and H4 acetylation | + | − | + |
| H3K4 methylation | + | − | + |
| H3K9 methylation | − | + | +/− |
| H3K27 dimethylation | + | − | + |
| H3K27 trimethylation | − | + | − |
