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. 2016 Aug 16;14(8):154. doi: 10.3390/md14080154

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© 2016 by the author; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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Silencing of TP53 family members by siRNA upon exposure of tumor cells selected marine drugs. Tumor cells (SCC-11 in panel A; U87-MG in panel B; and RKO I panel C) were transfected with the scrambled siRNA (Scr RNA) and siRNA against TP63 (panel A), TP73 (panel B), and TP53 (panel C) for 48 h, and were subsequently treated with control media (Con) and indicated marine drugs (CA2, 30 nM, PMA, 7.5 µM, and ILQ, 10 µM) for an additional 16 h. Expression of TP53 family members was examined by immunoblotting with indicated antibodies. Level of β-tubulin served as a loading control.