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. 2016 Aug 16;14(8):154. doi: 10.3390/md14080154

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© 2016 by the author; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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Silencing of TP53 family members by siRNA modulate the transcription of tested autophagic genes (ATG7, ATG10, ATG5, UVRAG, BECN1, and ULK1) in tumor cells treated with selected marine drugs. Tumor cells (SCC-11 in panel A; U87-MG in panel B; and RKO I panel C) were transfected with the scrambled siRNA (Scr RNA) and siRNA against TP63 (panel A), TP73 (panel B), and TP53 (panel C) for 48 h, and were subsequently treated with control media (Con) and the indicated marine drugs (CA2, 30 nM, PMA, 7.5 µM, and ILQ, 10 µM) for an additional 16 h. QPCR analysis of gene targets in SCC-11 cells, U87-MG cells, and RKO cells. Three independent qPCR assays were performed in triplicate (± SD are indicated. * p < 0.05).