Table 3. Canine Lymphoma Patients Treated with High Dose Oral PAC-1 + Doxa.
| treatmentb |
||||||||
|---|---|---|---|---|---|---|---|---|
| patient | breed | sex | age (y) | weight (kg) | prior therapy | PAC-1 (mg/kg) | Dox (mg/m2) | outcome |
| 7 | Golden retriever | MC | 7 | 45 | naïve | 75 | 30 | PR |
| 8 | Golden retriever | FS | 6 | 44 | naïve | 75 | 30 | CR |
| 9 | Mixed breed | MC | 14 | 22 | naïve | 75 | 30 | CR |
| 10 | Golden retriever | MI | 11 | 39 | naïve | 100 | 30 | PR |
a
Abbreviations: FS, female spayed; MC, male castrated; MI, male intact; PR, partial response; CR, complete response.
b
PAC-1(oral tablet) was administered 4 h prior to treatment with doxorubicin (IV bolus). This treatment was repeated every 14 days, for three cycles.