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. 2016 Jul 8;291(35):18370–18383. doi: 10.1074/jbc.M115.713636

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© 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 2. — Neuroprotection by intracellular acidifying agent propionate against brain ischemia in vivo. A, TTC-stained brain sections (image, left) and summary data (bar graph, right) showing increased infarct area (infarct volume) in brains from quinine-injected mice but reduction in infarct area (infarct volume) in brains from propionate-injected mice (one-way ANOVA, effect of treatment, F_(2,14) = 9.36, p = 0.0026. Tukey's multiple comparisons test, **, p < 0.01 compared with aCSF; ##, p < 0.01 compared with quinine). B, summary data showing significantly reduced ischemia-induced infarct volume in PcTX1-injected mice. The infarct volume was not different in PcTX1 plus quinine or PcTX1 plus propionate-injected mice compared with PcTX1-alone injected mice (one-way ANOVA, F_(3,15) = 8.13, p = 0.0019. Tukey's multiple comparisons test, **, p < 0.01; ***, p < 0.001 compared with aCSF).