FIGURE 5.

Effects of changing intracellular pH on pH dose-response curve for ASIC1a and ASIC2a subunits. A, representative traces and summary data showing the shift in activation curve of ASIC1a currents by the intracellular alkalizing agent quinine. pH₅₀ values were significantly increased in the presence of quinine (n = 6, t₍₅₎ = 2.9, paired t test, p < 0.05). B, representative traces and summary data showing the shift in pH₅₀ of ASIC2a currents by quinine. Intracellular alkalization by quinine significantly increased pH₅₀ (n = 6, t₍₅₎ = 5.2, paired t test, p < 0.01).