Table 4.

Comparison of HRQoL according to the EQ-5D utility value in MPS IVA (Morquio A) patients with different levels of mobility impairment and other serious chronic diseases

Disease	HRQoL mean utilitya
MPS IVA: adults, no wheelchair [28]	0.846
MPS IVA: adults, sometimes wheelchair [28]	0.582
MPS IVA: adults, always wheelchair [28]	0.057
Multiple sclerosis, walking-aid [75]	0.460
Multiple sclerosis, bedridden [75]	−0.195
Moderate to severe rheumatoid arthritis [76]	0.489
Chronic ischaemic heart disease [77]	0.640
Non-insulin dependent diabetes mellitus [77]	0.670

^aEQ-5D utility scores were calculated using a time tradeoff method [78]. This generates scores ranging from −0.59 to 1, where 1 means full health and zero stands for death. Negative scores could be emotively interpreted as a health state “worse than death”. Tradeoff tariffs used differed depending on the ethnic background of patients