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. 2016 Aug 25;9(1):467. doi: 10.1186/s13071-016-1747-3

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Sheep host hemoglobin levels vary in a tissue-specific manner in response to A. phagocytophilum infection in ticks. a Cell compartment classification of differentially represented sheep host proteins in infected female tick midguts and salivary glands. b Venn diagram of the sheep host hemoglobin differentially represented in infected vs uninfected tick tissues. c Differential host hemoglobin protein representation in response to A. phagocytophilum infection in tick midguts and salivary glands. d Hemoglobin levels in tick midguts and salivary glands from A. phagocytophilum-infected and uninfected ticks determined by ELISA in individual tick protein extracts, represented as the mean + standard deviation (SD) and compared between samples from infected and uninfected ticks by Student’s t-test with unequal variance (P < 0.05; 2 biological replicates)