Table 6.

Univariable and multivariable analyses of factors associated with cognitive disorders after acute ischemic stroke

	Univariable			Multivariable
Variables	P	OR	95 % CI	P	OR	95 % CI
Gender, male	0.239	0.729	0.431–1.234
Age	0.001	1.043	1.018–1.068	0.001	1.039	1.016–1.064
BMI	0.623	0.982	0.913–1.056
Years of education	<0.001	0.817	0.772–0.866	<0.001	0.808	0.757–0.861
Hypertension	0.324	1.207	0.831–1.755
Diabetes	<0.001	1.276	1.175–1.385	0.341	1.400	0.700–2.797
Coronary heart disease	0.388	1.380	0.664–2.870
History of smoking	0.367	1.226	0.788–1.907
History of drinking	0.524	1.221	0.661–2.254
Family history of dementia	0.001	1.219	1.082–1.374	0.055	0.242	0.057–1.031
History of stroke	0.021	1.742	1.087–2.791	0.025	1.723	1.071–2.771
High TC	0.629	0.791	0.306–2.044
High TG	0.674	1.078	0.760–1.529
Low HDL-C	0.088	0.650	0.396–1.066
High LDL-C	0.900	1.025	0.694–1.514
High Non-HDL-C	0.034	3.115	1.088–8.917	<0.001	3.115	1.088–8.917
Normal level	0.170	1.691	0.799–3.579	0.088	1.691	0.799–3.579
Higher than normal	0.046	2.710	1.017–7.221	0.052	2.710	1.017–7.221
Critical high level	0.026	5.877	1.231–28.065	0.040	5.877	1.231–28.065
Very high level	0.013	7.006	1.502–32.675	0.932	7.006	1.502–32.675
High Hcy	<0.001	1.060	1.032–1.088	<0.001	1.057	1.031–1.084
hsCRP	0.515	0.990	0.960–1.021
Fasting hyperglycemia [n (%)]	0.285	1.084	0.935–1.256
High HbA1c	0.960	1.002	0.939–1.068
NPI	0.218	1.039	0.978–1.104
HAMD-21	0.001	1.224	1.089–1.375	0.001	1.284	1.177–1.401
ADL	0.141	1.012	0.996–1.029

BMI body mass index, Non-HDL-C non-high-density lipoprotein cholesterol, TC total cholesterol, TG triglycerides, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, HCY homocysteine, hsCRP serum high-sensitivity C-reactive protein, HbA1c glycated hemoglobin, MMSE mini-mental state examination, MoCA Montreal Cognitive Assessment, NPI Neuropsychiatric Inventory, ADL Activity of Daily Living Scale, HADM-21 Hamilton depression rating scale 21-item