Table 3.
Association between the mutation 184F and the geometric means of IC50 values for each drugs
| Drugs | Year | IC50 geometric mean (nM) | ||
|---|---|---|---|---|
| Y184 | 184F | p value | ||
| Amodiaquine | 2012 | 10.51 (19) | 15.02 (69) | 0.0671 |
| 2013 | 5.1 (16) | 6.277 (24) | 0.1992 | |
| Chloroquine | 2012 | 117.8 (20) | 104 (89) | 0.1094 |
| 2013 | 24.18 (15) | 28.10 (27) | 0.1036 | |
| Lumefantrine | 2012 | 493.6 (15) | 179.2 (69) | 0.0008 |
| 2013 | 155.9 (15) | 68.13 (23) | 0.1277 | |
| Artesunate | 2012 | 4.034 (12) | 3.041 (60) | 0.3808 |
| 2013 | 3.365 (17) | 3.693 (25) | 0.5729 | |
| Artemether | 2012 | – | – | – |
| 2013 | 5.997 (17) | 5.936 (25) | 0.9387 | |
The numbers in parentheses indicate the number of samples with wild or mutant allele