Table 2.
Inhibitory effect of the isolated compounds from Zea mays L. on protein tyrosine phosphatase 1β
| Compounds | Concentration (μg/mL) | Inhibition (%) | IC50 b (μg/ml) | IC50 (μM) |
|---|---|---|---|---|
| Suramina | 5 | 64.32 | 2.76 | |
| 2.5 | 46.46 | 3.94 | ||
| 1 | 10.69 | |||
| Protochtechuic acid (1) | 100 | <50.0 | - | - |
| Vanillic acid (2) | 100 | <50.0 | - | - |
| 2,4,6-Trihydroxybenzoic acid (3) | 100 | < 50.0 | - | - |
| p-Hydroxycinnamic acid (4) | 100 | < 50.0 | - | - |
| Ferulic acid (5) | 100 | 96.09 | 185.41 | |
| 50 | 64.53 | 35.97 | ||
| 10 | 28.33 | |||
| Hirsutrin (6) | 100 | < 50.0 | - | - |
| 3′-Methoxyhirsutrin (7) | 50 | 85.89 | 64.04 | |
| 25 | 36.84 | 30.61 | ||
| 10 | 15.02 | |||
| Cyanidin-3-glucoside (8) | 100 | < 50.0 | - | - |
| Pelargonidin-3-glucoside (9) | 100 | 55.05 | 210.81 | |
| 50 | 13.35 | 91.36 | ||
| 10 | 1.09 | |||
| Peonidin-3-glucoside (10) | 100 | < 50.0 | - | - |
| Cyanidin-3-(6”-malonylglucoside) (11) | 50 | 91.73 | 54.06 | |
| 25 | 36.24 | 28.95 | ||
| 10 | 18.54 | |||
| Peonidin-3-(6”-malonylglucoside) (12) | 100 | < 50.0 | - | - |
aSuramin was used as positive control
bThe IC50 value was defined as the half-maximal inhibitory concentration and mean of 3 duplication analyses of each sample