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. 2016 Aug 26;6:32265. doi: 10.1038/srep32265

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Copyright © 2016, The Author(s)

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(A,E) Silencing of NR1D2 resulted in downregulated IL-6 mRNA and secretion levels. NR1D2 siRNA (si.NR1D2) or negative control (si.NC) were transfected into NT-2 cells at 200 nM and harvested 48 h after transfection. (C) Upregulated IL-6 secretion levels in association with NR1D2 overexpression. (B,D) miR-210 reversed NR1D2-induced IL-6 mRNA expression and secretion. Flag-NR1D2 and miR-210 mimics were co-transfected into NT-2 cells. Cells were harvested 48 h after transfection. MNC: normal control mimics, M210: miR-210 mimics. All data are presented as the means ± SEMs from at least three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001.