Table 3.
pD2 and Emax (%) values of insulin-induced relaxation in mesenteric arteries of control or HFD-fed mice incubated with vehicle, VO-OHpic or TNF-α
| Groups | pD2 | Emax | ||
|---|---|---|---|---|
| Control | HFD | Control | HFD | |
| C57Bl/6J | 7.01 ± 0.15 (n = 5) | 6.02 ± 0.18 (n = 6)* | 80.8 ± 2.7 (n = 5) | 52.8 ± 6.8 (n = 5)* |
| C57Bl/6J_VO-OHpic | 6.93 ± 0.22 (n = 5) | 6.87 ± 0.11 (n = 7)# | 86.9 ± 1.9 (n = 5) | 78.0 ± 4.1 (n = 5)# |
| C57Bl/6J_TNF-α | 6.30 ± 0.14 (n = 6)* | – | 49.4 ± 2.7 (n = 6) | – |
| C57Bl/6J_TNF-α + VO-OHpic | 7.29 ± 0.13 (n = 6)& | – | 63.5 ± 1.6 (n = 6)*& | – |
Data represent the mean ± SEM of n experiments. Two-way ANOVA with Bonferroni post-test. * p < 0.05 vs. C57Bl/6J Control; # p < 0.05 vs. C57Bl/6J HFD; & p < 0.05 vs. C57Bl/6J_TNFα