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. 2016 Aug 25;13(1):196. doi: 10.1186/s12974-016-0683-7

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 10 — Telmisartan blocks oxidative changes to neurons in the spinal cords of NSV-infected mice. Immunohistochemical staining for 4-HNE, a lipid peroxidation product that accumulates in cell membranes following ROS exposure, is induced 4 days after NSV infection (b) compared to expression in uninfected control animals (a). Higher magnification views show prominent staining of neuronal cell membranes with less intense labeling of neuropil in ventral gray matter of infected animals (c). Treatment of NSV-infected mice with telmisartan (100 mg/kg/day) for 4 days blocks most of the observed 4-HNE immunoreactivity (d). Calibration bar = 250 μm in panels a, b and d; 20 μm in panel c