Fig. 12.

Nox-deficient mice are protected from NSV infection compared to WT controls, while telmisartan has no protective effect in Nox-deficient hosts. In the absence of any drug treatment, gp91/p47 DKO mice survived NSV infection much better than WT control animals (a). When gp91/p47 DKO mice were treated with either telmisartan (100 mg/kg/day) or a vehicle control, no survival difference between the two groups was observed (b). Statistical differences in outcome between these cohorts (n = 22 mice/group) were determined using a log-rank (Mantel-Cox) test. Individual p values are shown