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. 2016 Aug 25;13(1):196. doi: 10.1186/s12974-016-0683-7

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Telmisartan has no effect on the systemic or local CNS production of myeloid-related immune factors following NSV challenge. At peak inflammation (day 6), plasma and brain tissue was collected from mice (n = 5 mice per group) treated with telmisartan (100 mg/kg/day) compared to a vehicle control. Plasma samples were assayed without further manipulation. Tissue homogenates were first normalized to the total extracted protein content of each sample. Plasma and brain levels of myeloid-related immune factors were measured using a commercial assay according to the manufacturer’s instructions. Plasma (pg/ml) or brain (pg/mg total tissue protein) concentrations are shown. No differences in any vehicle- versus telmisartan-treated brain concentrations were identified