Figure 2.

Nalmefene attenuates uptake rates in brain slices from CIE-exposed mice. (A) Nalmefene concentration-dependently attenuated the maximal rate of uptake rate (V_max) in both groups, although this effect was greater in brain slices from CIE exposed animals compared to air-exposed mice; (B) nalmefene reduced the uptake rate in CIE-exposed animals to a level comparable to that found in air-exposed mice even; (C) nalmefene concentration-dependently decreased dopamine release similarly in the inhalation groups; (D) the KOR antagonist, norbinaltorphimine (norBNI) did not alter dopamine release in either inhalation group; (E) NorBNI reduced uptake rates in brain slices from CIE-exposed mice compared to controls. * p < 0.05 (CIE: chronic intermittent ethanol).