Table 1.

Kinetic parameters of [³H]dopamine uptake in HEK293 cells transiently expressing human multidrug and toxin extrusion (hMATE) 1, hMATE2-K and mouse (m) MATE1.

Kinetic Parameters	hMATE1	hMATE2-K	mMATE1
Km (mM)	0.56 ± 0.18 *	2.48 ± 0.65 ‡	0.53 ± 0.08
Vmax (nmol·mg·protein−1·min−1)	3.71 ± 0.15 *	7.69 ± 1.12	8.73 ± 0.08 ††
Vmax/Km (µL·mg·protein−1·min−1)	7.70 ± 1.67	3.44 ± 0.78 ‡‡	17.20 ± 2.72 †

Data represent the mean ± standard error (S.E.) of three separate experiments. * p < 0.05, hMATE1 vs. hMATE2-K unpaired t-test. ^‡ p < 0.05, ^‡‡ p < 0.01, hMATE2-K vs. mMATE1 unpaired t-test. ^† p < 0.05, ^†† p < 0.01, hMATE1 vs. mMATE1 unpaired t-test.