Table 4.

Half-maximal inhibitory concentration (IC₅₀) values of tyrosine kinase inhibitors on [³H]dopamine uptake mediated by hMATE1, hMATE2-K and mMATE1.

Transporter	Imatinib (µM)	Dasatinib (µM)	Nilotinib (µM)
hMATE1	1.1 ± 0.1	7.1 ± 0.6	>100
hMATE2-K	13.8 ± 4.4	4.1 ± 1.0	>100
mMATE1	100.6 ± 13.9	106.2 ± 7.0	>100

Imatinib and dasatinib data represent the mean ± S.E. of three separate experiments. Imatinib concentrations were 0, 0.3, 0.6, 1, 3 and 10 µM for hMATE1; 0, 2, 3, 6, 10 and 250 µM for hMATE2-K; and 0, 30, 60, 100, 150 and 250 µM for mMATE1. Dasatinib concentrations were 0, 0.3, 1, 3, 10 and 30 µM for hMATE1 and hMATE2-K and 0, 30, 60, 100, 150 and 200 µM for mMATE1.