Figure 1.

EtOH consumption and preference, quinine consumption and EtOH metabolism in Fkbp5 KO and WT mice. A significant increase in alcohol consumption (A) in male mice was observed in the KO mice at 9%, 12% and 15% EtOH concentrations when compared to WT mice. No significant increases in alcohol consumption (C) in female mice or preference (B,D) in either sex were observed. Lower total fluid consumption was observed (E) in male mice, but not (F) in female mice during the EtOH consumption test. KO and WT mice did not differ in quinine consumption (G). No differences in alcohol metabolism were found between KO and WT mice (H). *, p < 0.05, **, p < 0.01, ***, p < 0.001.