Table 2.
Alcohol-related variables in Chinese, Korean and Caucasian college students for two FKBP5 genotypes after co-varying for ALDH2*2 and ADH1B*2.
| SNP | FKBP5 Intron (rs1360780) | FKBP51 UTR (rs3800373) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Genotype | CC | CT/TT | – | – | – | TT | TG/GG | – | – | – |
| Statistic | M (SD) | M (SD) | F | p | Change in R2 | M (SD) | M (SD) | F | p | Change in R2 |
| Chinese | n = 180 | n = 160 | – | – | – | n = 183 | n = 157 | – | – | – |
| Quantity | 3.8 (6.02) | 2.9 (1.52) | 2.13 | 0.034 | 0.013 | 3.3 (2.11) | 2.9 (1.53) | 1.39 | 0.164 | 0.005 |
| Frequency | 10.9 (11.31) | 9.7 (9.61) | 0.69 | 0.491 | 0.001 | 10.7 (11.30) | 9.8 (9.64) | 0.34 | 0.731 | 0.001 |
| Binges | 3.3 (5.20) | 2.8 (4.70) | 1.96 | 0.051 | 0.010 | 3.2 (5.17) | 2.8 (4.74) | 1.60 | 0.110 | 0.007 |
| Max drinks | 9.1 (8.54) | 6.3 (5.21) | 3.69 | <0.001 | 0.037 | 8.7 (8.46) | 6.4 (5.21) | 2.84 | 0.005 | 0.022 |
| AUD symptoms | 1.4 (1.00) | 1.2 (0.65) | 2.33 | 0.021 | 0.015 | 1.4 (0.97) | 1.2 (0.65) | 1.99 | 0.048 | 0.012 |
| Korean | n = 188 | n = 146 | – | – | – | n = 198 | n = 136 | – | – | – |
| Quantity | 4.2 (2.48) | 3.8 (2.21) | 1.18 | 0.238 | 0.004 | 4.1 (2.44) | 3.9 (2.20) | 0.33 | 0.741 | 0.001 |
| Frequency | 15.1 (14.89) | 12.2 (11.99) | 1.63 | 0.105 | 0.008 | 14.8 (15.01) | 12.5 (11.97) | 0.89 | 0.374 | 0.002 |
| Binges | 6.1 (8.17) | 5.2 (7.88) | 1.37 | 0.172 | 0.006 | 5.8 (7.99) | 5.4 (8.03) | 0.58 | 0.560 | 0.001 |
| Max drinks | 12.1 (9.89) | 10.4 (7.32) | 1.57 | 0.118 | 0.007 | 11.7 (9.73) | 10.7 (7.20) | 0.52 | 0.603 | 0.000 |
| AUD symptoms | 2.1 (1.77) | 1.7 (1.29) | 2.40 | 0.017 | 0.017 | 2.0 (1.72) | 1.7 (1.31) | 1.95 | 0.052 | 0.011 |
| Caucasian | n = 217 | n = 220 | – | – | – | n = 203 | n = 235 | – | – | – |
| Quantity | 3.1 (1.86) | 3.3 (2.24) | 0.21 | 0.65 | 0.000 | 3.2 (1.98) | 3.2 (2.20) | 0.00 | 0.98 | 0.000 |
| Frequency | 24.5 (18.80) | 24.2 (17.19) | 0.04 | 0.84 | 0.000 | 24.2 (18.40) | 24.1 (17.42) | 0.08 | 0.77 | 0.000 |
| Binges | 8.2 (12.16) | 8.0 (10.51) | 0.20 | 0.65 | 0.000 | 8.2 (12.28) | 8.0 (10.63) | 0.05 | 0.82 | 0.000 |
| Max drinks | 13.9 (10.13) | 14.2 (11.83) | 0.23 | 0.63 | 0.001 | 14.0 (10.35) | 13.9 (11.42) | 0.06 | 0.81 | 0.000 |
| AUD symptoms | 1.0 (1.71) | 1.0 (1.61) | 0.10 | 0.76 | 0.000 | 1.0 (1.75) | 1.0 (1.58) | 0.63 | 0.43 | 0.001 |
Raw scores reported for means and standard deviations. In the analyses, alcohol variables were log transformed to adjust for right-tailed distributions. ALDH2*2 and ADH1B*2 were covaried in all analyses, but no Caucasian possessed an ALDH2*2 allele. AUD, alcohol use disorder. Bolded p-value indicated statistically significant at p < 0.05.