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. 2016 Aug 9;17(8):1291. doi: 10.3390/ijms17081291

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© 2016 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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Genome-wide DNA methylation profiles of ulcerative colitis (UC) patients. (A) Comparison of genome-wide DNA methylation levels between UC tissues and normal control. 4397 probes showed significantly increased methylation level (hypermethylation) in UC tissues than normal colon (NC). However, 420 probes showed decreased methylation level (hypomethylation) in UC tissues than NC. p-values were calculated by Mann-Whitney U test; (B) Distributions of CpGs according to genome annotation. Most altered CpG sites in UC are located in CpG islands near the promoter regions; (C) Unsupervised clustering analysis of the normal colon (NC) and UC patient tissues (UC). The color gradient from white to red displays the β-values ranging from 0 (unmethylated) to 1 (fully methylated).