Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Remote metastasis formation by circulating tumor cells (CTCs) undergoing epithelial to mesenchymal transition-mesenchymal-to-epithelial transition (EMT-MET) changes of their cellular characteristics. Single cells dissolve from the primary tumour, adopt mesenchymal properties, enabling them to invade into the blood stream, after extravasation CTCs regain epithelial characteristics, thus they can seed in secondary tissues, building bud for remote metastasis formation.
