Table 3.

Meta-analyses investigating vitamin C and cardiovascular markers.

Meta-Analysis Topic	Number of Studies	Total Participants (n)	Trial Sizes (n)	Trial Durations	Vitamin C Supplement Dosages	Outcome
Arterial Stiffness [26]	20	1909	8 to 1162	8 h to 2635 days	120 to 4000 mg daily	Arterial stiffness was reduced with vitamin E and combined antioxidant supplement, but not with vitamin C alone
Endothelial Function [27]	46 (17 supplemented with vitamin C alone)	1817 (478 in trials that supplemented with vitamin C alone)	7 to 197	4 to 240 weeks	500 to 2000 mg daily	Significant improvements in endothelial function
Lipid Profile [28]	40	1981	8 to 305	2 to 240 weeks	125 to 4500 mg daily	No significant change in blood lipids
Blood Pressure [29]	29	1407	10 to 120	2 to 26 weeks	60 to 4000 mg daily	Vitamin C supplementation reduced systolic and diastolic blood pressure